| Grand Challenge 1 | Health, demographic change and wellbeing |
| Grand Challenge 2 | Food security, sustainable agriculture and forestry, marine and maritime and water research, and the bio economy |
| Grand Challenge 3 | Secure, clean and efficient energy |
| Grand Challenge 4 | Smart, green and integrated transport |
| Grand Challenge 5 | Climate action, environment, resource efficiency and raw materials |
| Grand Challenge 6 | Europe in a changing world – inclusive, innovative and reflective societies |